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In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic. User Name Remember Me? The above post was thanked by: TIBC correlates directly with transferrin saturation.

Sideroblastic Anaemia

Now in the early stages, not enough iron becomes trapped by mitochondria or picked up by bone macrophages, so the TIBC levels are normal as the iron spilling out in the serum is binding to transferrin and the ferritin levels are slowly increasing.

But in later stages, the ferritin levels increase significantly due to increased uptake by macrophagesthus resulting in decreased TIBC levels.

This is how I understood it. I would also go through Pathoma for this topic as it's well explained.

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  • anemia; seborrheic dermatitis; glossitis; angular chelitis; peripheral neuropathy; confusion; seizures. Evaluation. Labs. normal or reduced TIBC; ↑ serum iron, ↑ ferritin. Bone marrow stain. ringed sideroblasts; Prussian blue stain - most accurate test. Treatment. Sometimes responsive to pyridoxine (Vitamin B6 supplements).
  • Presentation. Anemia; Physical exam findings. seborrheic dermatitis; glossitis; angular chelitis; peripheral neuropathy; confusion; seizures. Evaluation. Labs. ↓ MCV and TIBC; ↑ serum iron and ferritin. Blood smear. Pappenheimer bodies. Bone marrow stain shows ringed sideroblasts (See above). Prussian blue stain is .
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Originally Posted by abdallah You currently have 0 posts. Originally Posted by coliris. You are getting the idea mixed, so here is the thing. Look at it as if you were eating That's the easiest way I could explain, I hope that helps. I wanted to say what I already said. You don't really measure the transferrin molecules directly, you measure its ability to BIND iron, to saturate; that's what really matters and you measure that indirectly with TIBC.

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Find All Thanked Posts. Step 1 Only Posts: Originally Posted by coliris You are getting the idea mixed, so here is the thing. Originally Posted by abdallah48 so you wanted to say that when iron in blood increases so the transferrin will be less depending on the fact that iron is binding to it but these is the concept of saturation not the number of protiens secreted from liver "transfferin".

Originally Posted by coliris I wanted to say what I already said. Originally Posted by abdallah48 Thank you very much I got the idea I just had some confusion. Options Quote message in reply? Password Please enter a password for your user account. Note that passwords are case-sensitive. Choose "" if you don't want to tell. IMG for all other medical schools.

Switch to Hybrid Mode. Switch to Threaded Mode. Anemia of chronic disease and TIBC. Lactation; decreased progesterone or decreased estrogen!

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  1. TIBC usually correlates inversely with Serum ferritin levels, so in most anemias, where the serum ferritin levels are high, TIBC is low. TIBC correlates directly with transferrin saturation. Now in the early stages, not enough iron becomes trapped by mitochondria or picked up by bone macrophages, so the.:
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