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These studies highlight Eisai's current product portfolio and oncology pipeline, reinforcing the company's commitment to patients and their families affected by cancer. Post hoc analysis of relationship between baseline white blood cell count and renal and hepatic function and response in a randomized phase III trial of Decitabine in patients age 65 or older with acute myeloid leukemia. The information discussed in this release is about investigational agents that are not Food and Drug Administration FDA -approved and investigational uses for FDA-approved products.

It is not intended to convey conclusions of efficacy and safety. There is no guarantee that any of these agents will successfully complete clinical development or gain FDA approval. Halaven is indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease.

Prior therapy should have included an anthracycline and a taxane either in the adjuvant or metastatic setting.

Sideroblastic Anemia: two patients

Your doctor should do a blood test to monitor your blood cells before you receive each dose of HALAVEN, and should monitor you more often if you develop lower white blood cells. If you develop severe neutropenia lasting longer than 7 days or neutropenia with a fever, your next dose of HALAVEN should be delayed and reduced.

Neutropenia with a fever can result in serious infections that could lead to hospitalization or death. Call your healthcare provider immediately if you have any of the following symptoms; fever temperature above You should be monitored closely for signs of neuropathy.

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You should not do both. This can cause irregular heartbeats that may lead to death.

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Dacogen is a nucleoside metabolic inhibitor indicated for treatment of patients with myelodysplastic syndromes MDS including previously treated and untreated, de novo and secondary MDS of all French-American-British subtypes refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia and intermediate-1, intermediate- 2, and high-risk International Prognostic Scoring System groups.

Complete blood and platelet counts should be performed as needed to monitor response and toxicity but at a minimum prior to each dosing cycle. After administration of the recommended dosage for the first cycle, treatment for subsequent cycles should be adjusted if indicated by dose adjustment guidelines. Women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with DACOGEN and for 1 month following completion of treatment.

Women of childbearing potential should be counseled to use effective contraception during this time.

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Men with female partners of childbearing potential should use effective contraception during this time. Bone marrow suppression was the most frequent cause of dose reduction, delay, and discontinuation.

Six patients had fatal events associated with their underlying disease and myelosuppression anemia, neutropenia, and thrombocytopenia that were considered at least possibly related to drug treatment. Of the 83 DACOGEN-treated patients, 8 permanently discontinued therapy for adverse events compared to 1 of 81 patients in the supportive care arm.

Seventy-eight percent of patients had dose delays, the median duration of this delay was 7 days. Hematologic toxicities and infections were the most frequent causes of dose delays and discontinuation. Nineteen of 99 patients permanently discontinued therapy for adverse events. Other Casino sideroblasts ringed hair occurring reactions include fatigue, pyrexia, nausea, cough, petechiae, constipation, diarrhea, and hyperglycemia. For full prescribing information, please see http: Eisai Oncology is dedicated to discovering, developing and producing innovative oncology therapies that can help make a difference and impact the lives of patients and their families.

This passion for people is part of Eisai's human health care hhc mission, which strives for better understanding of the needs of patients and their families to increase the benefits health care provides.

Our commitment to meaningful progress in oncology research, built on scientific expertise, is supported by a global capability to conduct discovery and preclinical research, and develop small molecules, biologic and supportive care agents for cancer across multiple indications.

Since that time, Eisai Inc. Eisai's key areas of commercial focus are neurology and oncology.

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The company serves as the U. Eisai has a global product creation organization that includes U.

For more information about Eisai, please visit www. The technology has been successfully applied to a broad variety of cell lines and organisms to yield genetically diverse offspring that are suitable for pharmaceutical product development in the areas of antibody therapeutics, protein therapeutics, product manufacturing, drug target discovery, and improved output traits for commercial applications.

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Casino sideroblasts ringed hair company is currently focusing its platform on the development and manufacturing of therapeutic antibodies for the treatment of cancer, inflammation and infectious disease. For more information, please visit www. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide healthcare system.

Join PR Newswire for Journalists to access all of the free services designated to make your job easier. In need of subject matter experts for your story? Submit a free ProfNet request and find the sources you need. Journalists and Bloggers The news you need, when you need it. Jun 22, Apr 30, Release contains wide tables. Jan 09, Looking to send a news release with PR Newswire?

Take advantage of the world's leading distribution platform. Sign up to get started Request more information Have an account? News in Focus Browse News Releases. Eribulin Mesylate Abstract No: Decitabine for Injection Abstract No: Post hoc analysis of relationship between baseline white blood cell count and renal and hepatic function and response in a randomized phase III trial of Decitabine in patients age 65 or older with acute myeloid leukemia Poster Session.

Lenvatinib E Abstract No:

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